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Issue 10, 2007
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Survival of the fittest polymorph: how fast nucleater can lose to fast grower

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Abstract

Controlling the crystallization of a liquid able to yield multiple polymorphs is often assumed to be a matter of controlling the initial nucleation. Recent studies found that this view is flawed because an early nucleating polymorph can nucleate another, faster-growing polymorph. We review how the phenomenon is controlled by thermodynamic and kinetic factors and how it can aid the discovery of new polymorphs. The selective crystallization of a polymorph depends not only on the initial nucleation but also on the cross-nucleation between polymorphs and the relative growth rates of polymorphs.

Graphical abstract: Survival of the fittest polymorph: how fast nucleater can lose to fast grower

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Publication details

The article was received on 18 Jun 2007, accepted on 16 Jul 2007 and first published on 30 Jul 2007


Article type: Highlight
DOI: 10.1039/B709260C
Citation: CrystEngComm, 2007,9, 847-851
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    Survival of the fittest polymorph: how fast nucleater can lose to fast grower

    L. Yu, CrystEngComm, 2007, 9, 847
    DOI: 10.1039/B709260C

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