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Issue 8, 2007
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Comparing entire crystal structures: structural genetic fingerprinting

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Abstract

This paper describes a proof-of-concept example for a method that allows the calculation of a similarity index between whole molecular crystal structures; this has been termed ‘structural genetic fingerprinting’. It is based on the use of fingerprint plots derived from Hirshfeld surfaces coupled with cluster analysis and associated multivariate statistics. Using this formalism, it is possible to show quantitatively (using correlation coefficients) that, for example naphthalene is more similar to anthracene than to benzene, and moreover that benzodicoronene is more similar to anthrabenzonaphthopentacene than naphthalene is to anthracene. Whereas the correlation coefficients themselves obtained say nothing about the ways in which the patterns of intermolecular interactions are similar or different for two different structures, the fingerprint plots do contain such information. In principle this method for quantifying structural similarities of whole molecular crystal structures should be both robust and generally applicable. This method is potentially applicable to datasets consisting of many hundreds or even thousands of structures.

Graphical abstract: Comparing entire crystal structures: structural genetic fingerprinting

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Publication details

The article was received on 20 Mar 2007, accepted on 14 May 2007 and first published on 01 Jun 2007


Article type: Paper
DOI: 10.1039/B704177B
Citation: CrystEngComm, 2007,9, 648-652
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    Comparing entire crystal structures: structural genetic fingerprinting

    A. Parkin, G. Barr, W. Dong, C. J. Gilmore, D. Jayatilaka, J. J. McKinnon, M. A. Spackman and C. C. Wilson, CrystEngComm, 2007, 9, 648
    DOI: 10.1039/B704177B

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