Issue 43, 2007
From the journal:

Chemical Communications

Identification of protease substrates by combinatorial profiling on TentaGel beads†

Jacob Kofoed‡a  and  Jean-Louis Reymond*a  

* Corresponding authors

a Department of Chemistry and Biochemistry, University of Berne, Freiestrasse 3, CH-3012 Berne, Switzerland
E-mail: jean-louis.reymond@ioc.unibe.ch
Fax: +41 31 631 80 57
Tel: +41 31 631 43 25

Abstract

Reacting a 65 536 member combinatorial library of octapeptides on TentaGel beads with various proteases followed by selective staining of the free amino termini at the reacted bead surface and sequence determination by amino acid analysis allowed the rapid identification of protease substrates.

Graphical abstract: Identification of protease substrates by combinatorial profiling on TentaGel beads

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Article information

DOI
https://doi.org/10.1039/B713595E
Article type
Communication
Submitted
05 Sep 2007
Accepted
05 Oct 2007
First published
11 Oct 2007

Chem. Commun., 2007, 4453-4455

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Identification of protease substrates by combinatorial profiling on TentaGel beads

J. Kofoed and J. Reymond, Chem. Commun., 2007, 4453 DOI: 10.1039/B713595E

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