Stabilisation of human telomeric quadruplex DNA and inhibition of telomerase by a platinum–phenanthroline complex

Julie E. Reed; Stephen Neidle; Ramon Vilar

doi:10.1039/B709898G

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Chemical Communications

Issue 42, 2007

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Stabilisation of human telomeric quadruplex DNA and inhibition of telomerase by a platinum–phenanthroline complex

Julie E. Reed , Stephen Neidle and Ramon Vilar

Chem. Commun., 2007, 4366-4368

DOI: 10.1039/B709898G
Received 29 Jun 2007, Accepted 26 Jul 2007
First published on the web 13 Aug 2007

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Two new mono-substituted phenanthroline ligands and their platinum(II) square planar complexes have been prepared; one of the complexes has been shown to induce a high degree of quadruplex DNA stabilisation and to inhibit telomerase.

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Chemical Communications

Stabilisation of human telomeric quadruplex DNA and inhibition of telomerase by a platinum–phenanthroline complex

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