An iron carbonyl approach to the influenza neuraminidase inhibitor oseltamivir

Karen M. Bromfield; Henrik Gradén; Daniel P. Hagberg; Thomas Olsson; Nina Kann

doi:10.1039/B703295A

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Chemical Communications

Issue 30, 2007

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An iron carbonyl approach to the influenza neuraminidase inhibitor oseltamivir

Karen M. Bromfield , Henrik Gradén , Daniel P. Hagberg , Thomas Olsson and Nina Kann

Chem. Commun., 2007, 3183-3185

DOI: 10.1039/B703295A
Received 05 Mar 2007, Accepted 16 May 2007
First published on the web 25 May 2007

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Abstract
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A novel synthetic route towards oseltamivir, an influenza neuraminidase inhibitor, has been achieved employing a cationic iron carbonyl complex, providing an alternate pathway with the potential to access diverse analogues.

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Experimental details and characterisation
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Selected NMR spectra
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Karen M. Bromfield
Henrik Gradén
Daniel P. Hagberg
Thomas Olsson
Nina Kann

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Chemical Communications

An iron carbonyl approach to the influenza neuraminidase inhibitor oseltamivir

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