Jump to main content
Jump to site search

Issue 25, 2007
Previous Article Next Article

Incorporation of N-heterocyclic cations into proteins with a highly directed chemical modification

Author affiliations

Abstract

N-Heterocyclic cations are incorporated into proteins using 5-(2-bromoethyl)phenanthridinium bromide, which selectively reacts with either cysteine or lysine residues, resulting in ethylphenanthridinium (Phen) or highly stable cyclised dihydro-imidazo-phenanthridinium (DIP) adducts respectively; these modifications have been found to manipulate the observed structure of lysozyme and bovine serum albumin by AFM.

Graphical abstract: Incorporation of N-heterocyclic cations into proteins with a highly directed chemical modification

Back to tab navigation

Supplementary files

Publication details

The article was received on 19 Feb 2007, accepted on 08 May 2007 and first published on 29 May 2007


Article type: Communication
DOI: 10.1039/B702575K
Citation: Chem. Commun., 2007,0, 2581-2583
  •   Request permissions

    Incorporation of N-heterocyclic cations into proteins with a highly directed chemical modification

    N. McMillan, L. V. Smith, J. M. de la Fuente, A. D. C. Parenty, N. Gadegaard, A. R. Pitt, K. Thomson, C. MacKenzie, S. M. Kelly and L. Cronin, Chem. Commun., 2007, 0, 2581
    DOI: 10.1039/B702575K

Search articles by author

Spotlight

Advertisements