Jump to main content
Jump to site search

Issue 31, 2007
Previous Article Next Article

Mesoporous silica nanoparticle based controlled release, drug delivery, and biosensor systems

Author affiliations

Abstract

Recent advancements in controlling the surface properties and particle morphology of the structurally defined mesoporous silica materials with high surface area (>700 m2 g−1) and pore volume (>1 cm3 g−1) have significantly enhanced their biocompatibility. Various methods have been developed for the functionalization of both the internal pore and exterior particle surfaces of these silicates with a tunable pore diameter ranging from 2 to 30 nm and a narrow pore size distribution. Herein, we review the recent research progress on the design of functional mesoporous silica materials for stimuli-responsive controlled release delivery of pharmaceutical drugs, genes, and other chemicals. Furthermore, the recent breakthroughs in utilizing these nanoscale porous materials as sensors for selective detections of various neurotransmitters and biological molecules are summarized.

Graphical abstract: Mesoporous silica nanoparticle based controlled release, drug delivery, and biosensor systems

Back to tab navigation
Please wait while Download options loads

Publication details

The article was received on 05 Feb 2007, accepted on 02 Mar 2007 and first published on 20 Mar 2007


Article type: Feature Article
DOI: 10.1039/B701744H
Citation: Chem. Commun., 2007, 3236-3245
  •   Request permissions

    Mesoporous silica nanoparticle based controlled release, drug delivery, and biosensor systems

    B. G. Trewyn, S. Giri, I. I. Slowing and V. S.-Y. Lin, Chem. Commun., 2007, 3236
    DOI: 10.1039/B701744H

Search articles by author