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Issue 20, 2007
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Mupirocin H, a novel metabolite resulting from mutation of the HMG-CoA synthase analogue, mupH in Pseudomonas fluorescens

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Abstract

Mutation of the HMG-CoA synthase encoding mupH gene in Pseudomonas fluorescens gives rise to a new metabolite formed from a truncated polyketide intermediate, providing in vivo evidence for the roles of mupH and cognate genes found in several “AT-less” and other bacterial PKS gene clusters responsible for the biosynthesis of diverse metabolites containing acetate/propionate derived side chains.

Graphical abstract: Mupirocin H, a novel metabolite resulting from mutation of the HMG-CoA synthase analogue, mupH in Pseudomonas fluorescens

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Publication details

The article was received on 15 Jan 2007, accepted on 26 Jan 2007 and first published on 22 Feb 2007


Article type: Communication
DOI: 10.1039/B700613F
Citation: Chem. Commun., 2007, 2040-2042
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    Mupirocin H, a novel metabolite resulting from mutation of the HMG-CoA synthase analogue, mupH in Pseudomonas fluorescens

    J. Wu, S. M. Cooper, R. J. Cox, J. Crosby, M. P. Crump, J. Hothersall, T. J. Simpson, C. M. Thomas and C. L. Willis, Chem. Commun., 2007, 2040
    DOI: 10.1039/B700613F

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