Issue 23, 2007

New insights into the enantioselectivity in the hydrogenation of prochiral ketones

Abstract

The high enantioselectivity in the hydrogenation of acetophenone catalysed by trans-Ru(H)2(S,S-dpen)(S-xylbinap) is explained in terms of the existence of a stable intermediate formed when the reactant enters the catalyst pocket fixing the molecular orientation.

Graphical abstract: New insights into the enantioselectivity in the hydrogenation of prochiral ketones

Supplementary files

Article information

Article type
Communication
Submitted
08 Nov 2006
Accepted
22 Jan 2007
First published
12 Mar 2007

Chem. Commun., 2007, 2381-2383

New insights into the enantioselectivity in the hydrogenation of prochiral ketones

S. A. French, D. D. Tommaso, A. Zanotti-Gerosa, F. Hancock and C. R. A. Catlow, Chem. Commun., 2007, 2381 DOI: 10.1039/B616210J

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