Issue 3, 2007
From the journal:

Chemical Communications

A convenient new procedure for converting primary amides into nitriles

Chun-Wei Kuo,ab   Jia-Liang Zhu,c   Jen-Dar Wu,a   Cheng-Ming Chu,ab   Ching-Fa Yao*b  and  Kak-Shan Shia*a  

* Corresponding authors

a Division of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli County, Taiwan, R.O.C
E-mail: ksshia@nhri.org.tw

b Department of Chemistry, National Taiwan Normal University, Taipei, Taiwan, R.O.C
E-mail: cheyaocf@scc.ntnu.edu.tw

c Department of Chemistry, National Dong-Hwa University, Hualien, Taiwan, R.O.C.

Abstract

An operationally simple and high-yielding procedure has been developed for the conversion of primary amides to the corresponding nitriles, using ethyl dichlorophosphate/DBU as the mild dehydrating agent.

Graphical abstract: A convenient new procedure for converting primary amides into nitriles

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Article information

DOI
https://doi.org/10.1039/B614061K
Article type
Communication
Submitted
28 Sep 2006
Accepted
18 Oct 2006
First published
27 Oct 2006

Chem. Commun., 2007, 301-303

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A convenient new procedure for converting primary amides into nitriles

C. Kuo, J. Zhu, J. Wu, C. Chu, C. Yao and K. Shia, Chem. Commun., 2007, 301 DOI: 10.1039/B614061K

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