Issue 26, 2007

Rhodium(i)-catalyzed hydroaminomethylation of 2-isopropenylanilines as a novel route to 1,2,3,4-tetrahydroquinolines

Abstract

A new atom economical approach for the preparation of 1,2,3,4-tetrahydroquinolines can be achieved by means of the intramolecular hydroaminomethylation of 2-isopropenylanilines, mediated by an ionic diamino rhodium catalyst that does not require phosphine—this reaction is highly chemo- and regioselective, and it occurs in good isolated yields.

Graphical abstract: Rhodium(i)-catalyzed hydroaminomethylation of 2-isopropenylanilines as a novel route to 1,2,3,4-tetrahydroquinolines

Supplementary files

Article information

Article type
Communication
Submitted
16 Feb 2007
Accepted
03 Apr 2007
First published
19 Apr 2007

Chem. Commun., 2007, 2710-2711

Rhodium(I)-catalyzed hydroaminomethylation of 2-isopropenylanilines as a novel route to 1,2,3,4-tetrahydroquinolines

T. O. Vieira and H. Alper, Chem. Commun., 2007, 2710 DOI: 10.1039/B702497E

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