Organocatalytic enantioselective aza-Michael reaction of nitrogen heterocycles and α,β-unsaturated aldehydes

Uxue Uria; Jose L. Vicario; Dolores Badía; Luisa Carrillo

doi:10.1039/B700831G

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Organocatalytic enantioselective aza-Michael reaction of nitrogen heterocycles and α,β-unsaturated aldehydes†

Uxue Uria,^a Jose L. Vicario,*^a Dolores Badía^a and Luisa Carrillo^a

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* Corresponding authors

^a Department of Organic Chemistry II, Faculty of Science and Technology, University of the Basque Country, P. O. Box 644, Spain
E-mail: joseluis.vicario@ehu.es
Fax: +34 94 601 2748
Tel: +34 94 601 5454

Abstract

The asymmetric organocatalytic aza-Michael reaction of several nitrogen heterocycles and α,β-unsaturated aldehydes has been studied in detail; under the optimised conditions, the conjugate addition products have been obtained in high to excellent enantioselectivities.

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Supplementary files

Experimental procedures, characterisation of all new compounds, copies of their ¹H and ¹³C NMR spectra, and chiral HPLC chromatograms PDF (1151K)

Article information

DOI: https://doi.org/10.1039/B700831G
Article type: Communication
Submitted: 18 Jan 2007
Accepted: 28 Feb 2007
First published: 19 Mar 2007

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Chem. Commun., 2007, 2509-2511

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Organocatalytic enantioselective aza-Michael reaction of nitrogen heterocycles and α,β-unsaturated aldehydes

U. Uria, J. L. Vicario, D. Badía and L. Carrillo, Chem. Commun., 2007, 2509 DOI: 10.1039/B700831G

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Chemical Communications

Organocatalytic enantioselective aza-Michael reaction of nitrogen heterocycles and α,β-unsaturated aldehydes†

Abstract

Supplementary files

Article information

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Organocatalytic enantioselective aza-Michael reaction of nitrogen heterocycles and α,β-unsaturated aldehydes

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