Issue 23, 2007
From the journal:

Chemical Communications

New insights into the enantioselectivity in the hydrogenation of prochiral ketones†

Samuel A. French,*a   Devis Di Tommaso,b   Antonio Zanotti-Gerosa,c   Fred Hancockc  and  C. Richard A. Catlowbd  

* Corresponding authors

a Johnson Matthey Technology Centre, Blount's Court, Sonning Common, UK
E-mail: frencsa@matthey.com
Fax: +44(0)1189242195
Tel: +44(0)1189242195

b Davy Faraday Research Laboratory, The Royal Institution of Great Britain, 21 Albemarle Street, London, UK
E-mail: devis@ri.ac.uk
Fax: +44(0)2076702958
Tel: +44(0)2076702922

c Johnson Matthey, Catalysis and Chiral Technologies, 28 Cambridge Science Park, Milton Road, Cambridge, UK
Fax: +44(0)1223 438037
Tel: +44(0)1223 225800

d Christopher Ingold Laboratories, Department of Chemistry, University College of London, 20 Gordon Street, London, UK
E-mail: c.r.a.catlow@ucl.ac.uk
Fax: +44 (0)20 7679 7463
Tel: +44 (0)20 7679 7482

Abstract

The high enantioselectivity in the hydrogenation of acetophenone catalysed by trans-Ru(H)2(S,S-dpen)(S-xylbinap) is explained in terms of the existence of a stable intermediate formed when the reactant enters the catalyst pocket fixing the molecular orientation.

Graphical abstract: New insights into the enantioselectivity in the hydrogenation of prochiral ketones

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Article information

DOI
https://doi.org/10.1039/B616210J
Article type
Communication
Submitted
08 Nov 2006
Accepted
22 Jan 2007
First published
12 Mar 2007

Chem. Commun., 2007, 2381-2383

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New insights into the enantioselectivity in the hydrogenation of prochiral ketones

S. A. French, D. D. Tommaso, A. Zanotti-Gerosa, F. Hancock and C. R. A. Catlow, Chem. Commun., 2007, 2381 DOI: 10.1039/B616210J

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