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Issue 9, 2007
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Inhibition of pyruvate decarboxylase from Z. mobilis by novel analogues of thiamine pyrophosphate: investigating pyrophosphate mimics

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Abstract

Replacement of the thiazolium ring of thiamine pyrophosphate with a triazole gives extremely potent inhibitors of pyruvate decarboxylase from Z. mobilis, with KI values down to 20 pM; this system was used to explore pyrophosphate mimics and several effective analogues were discovered.

Graphical abstract: Inhibition of pyruvate decarboxylase from Z. mobilis by novel analogues of thiamine pyrophosphate: investigating pyrophosphate mimics

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Publication details

The article was received on 01 Nov 2006, accepted on 27 Nov 2006 and first published on 08 Dec 2006


Article type: Communication
DOI: 10.1039/B615861G
Citation: Chem. Commun., 2007,0, 960-962
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    Inhibition of pyruvate decarboxylase from Z. mobilis by novel analogues of thiamine pyrophosphate: investigating pyrophosphate mimics

    K. M. Erixon, C. L. Dabalos and F. J. Leeper, Chem. Commun., 2007, 0, 960
    DOI: 10.1039/B615861G

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