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Issue 1, 2007
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Design, synthesis and biological evaluation of a macrocyclic discodermolide/dictyostatin hybrid

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Abstract

A 22-membered macrocyclic discodermolide/dictyostatin hybrid has been designed and synthesised; biological evaluation against a range of human cancer cell lines revealed significant levels of growth inhibition.

Graphical abstract: Design, synthesis and biological evaluation of a macrocyclic discodermolide/dictyostatin hybrid

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Publication details

The article was received on 18 Oct 2006, accepted on 01 Nov 2006 and first published on 23 Nov 2006


Article type: Communication
DOI: 10.1039/B615122A
Citation: Chem. Commun., 2007,0, 49-51
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    Design, synthesis and biological evaluation of a macrocyclic discodermolide/dictyostatin hybrid

    I. Paterson and N. M. Gardner, Chem. Commun., 2007, 0, 49
    DOI: 10.1039/B615122A

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