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Issue 12, 2007
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Viral MRI contrast agents: coordination of Gd by native virions and attachment of Gd complexes by azide–alkyne cycloaddition

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Abstract

Icosahedral virus particles decorated with a Gd(DOTA) analogue by Cu-mediated azidealkyne cycloaddition (CuAAC) and/or with Gd3+ ions by coordination to the viral nucleoprotein show increased T1 relaxivity relative to free Gd(DOTA) complexes in solution.

Graphical abstract: Viral MRI contrast agents: coordination of Gd by native virions and attachment of Gd complexes by azide–alkyne cycloaddition

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Publication details

The article was received on 17 Oct 2006, accepted on 14 Dec 2006 and first published on 15 Jan 2007


Article type: Communication
DOI: 10.1039/B615084E
Citation: Chem. Commun., 2007,0, 1269-1271
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    Viral MRI contrast agents: coordination of Gd by native virions and attachment of Gd complexes by azide–alkyne cycloaddition

    D. E. Prasuhn, Jr., R. M. Yeh, A. Obenaus, M. Manchester and M. G. Finn, Chem. Commun., 2007, 0, 1269
    DOI: 10.1039/B615084E

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