Issue 11, 2007
From the journal:

Analyst

Selective detection of extracellularglutamate in brain tissue using microelectrode arrays coated with over-oxidized polypyrrole

Eric Walker,a   Jianjun Wang,b   Naser Hamdi,†c   Harold G. Monbouquetteb  and  Nigel T. Maidment*a  

* Corresponding authors

a Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience & Human Behavior, University of California, Los Angeles, CA 90095, USA
E-mail: nmaidmen@ucla.edu
Fax: +1 310-825-7067
Tel: +1 310-206-7767

b Department of Chemical & Biomolecular Engineering, University of California, Los Angeles, CA 90095, USA

c Biomedical Engineering Interdepartmental Graduate Program, University of California, Los Angeles, CA 90095, USA

Abstract

We describe the selective measurement of extracellularglutamate concentration in rodent brain using ceramic-based platinum microelectrode arrays (MEAs) coated with electropolymerized, over-oxidized polypyrrole (OPP) as a permselective barrier to interference from dopamine and ascorbate. OPP-coated MEAs displayed similar sensitivity (97 ± 9 nA µM−1 cm−2) and response time (ca. 1 s) to glutamate as previously described Nafion-coated MEAs but, unlike Nafion-coated MEAs, were unresponsive to 5 µM dopamine. Such OPP-coated MEAs afforded selective detection of evoked glutamate release in the dopamine-rich striatum of the mouse brain.

Graphical abstract: Selective detection of extracellularglutamate in brain tissue using microelectrode arrays coated with over-oxidized polypyrrole

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Article information

DOI
https://doi.org/10.1039/B706880H
Article type
Paper
Submitted
09 May 2007
Accepted
23 Aug 2007
First published
19 Sep 2007

Analyst, 2007,132, 1107-1111

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Selective detection of extracellularglutamate in brain tissue using microelectrode arrays coated with over-oxidized polypyrrole

E. Walker, J. Wang, N. Hamdi, H. G. Monbouquette and N. T. Maidment, Analyst, 2007, 132, 1107 DOI: 10.1039/B706880H

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