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Issue 11, 2007
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Selective detection of extracellularglutamate in brain tissue using microelectrode arrays coated with over-oxidized polypyrrole

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Abstract

We describe the selective measurement of extracellularglutamate concentration in rodent brain using ceramic-based platinum microelectrode arrays (MEAs) coated with electropolymerized, over-oxidized polypyrrole (OPP) as a permselective barrier to interference from dopamine and ascorbate. OPP-coated MEAs displayed similar sensitivity (97 ± 9 nA µM−1 cm−2) and response time (ca. 1 s) to glutamate as previously described Nafion-coated MEAs but, unlike Nafion-coated MEAs, were unresponsive to 5 µM dopamine. Such OPP-coated MEAs afforded selective detection of evoked glutamate release in the dopamine-rich striatum of the mouse brain.

Graphical abstract: Selective detection of extracellularglutamate in brain tissue using microelectrode arrays coated with over-oxidized polypyrrole

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Publication details

The article was received on 09 May 2007, accepted on 23 Aug 2007 and first published on 19 Sep 2007


Article type: Paper
DOI: 10.1039/B706880H
Citation: Analyst, 2007,132, 1107-1111
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    Selective detection of extracellularglutamate in brain tissue using microelectrode arrays coated with over-oxidized polypyrrole

    E. Walker, J. Wang, N. Hamdi, H. G. Monbouquette and N. T. Maidment, Analyst, 2007, 132, 1107
    DOI: 10.1039/B706880H

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