Issue 7, 2007
From the journal:

Analyst

Single molecule level detection of allophycocyanin by surface enhanced resonance Raman scattering

Colin D. McGuinness,*ab   Alexander M. Macmillan,c   Jan Karolin,c   W. Ewen Smith,b   Duncan Graham,b   John C. Pickupa  and  David J. S. Birchc  

* Corresponding authors

a Unit for Metabolic Medicine, 5th Floor, Thomas Guy House, Guy's Hospital, St. Thomas' Street, London, UK
E-mail: colin.mcguinness@kcl.ac.uk
Fax: +44(0)20 7188 0146
Tel: +44(0)20 7188 1909

b Centre for Molecular Nanometrology, Department of Pure & Applied Chemistry, University of Strathclyde, 295 Cathedral Street, Glasgow, UK

c Centre for Molecular Nanometrology, Department of Physics, University of Strathclyde, 107 Rottenrow, Glasgow, UK

Abstract

Single molecule level detection of the near-infrared fluorescent protein allophycocyanin (APC) has been achieved using surface enhanced resonance Raman scattering (SERRS). The detection limit using the peak height of the 440 cm−1 band was 1 × 10−13 mol l−1, compared to 2 × 10−12 mol l−1 for the fluorescence peak at 660 nm.

Graphical abstract: Single molecule level detection of allophycocyanin by surface enhanced resonance Raman scattering

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Article information

DOI
https://doi.org/10.1039/B706409H
Article type
Communication
Submitted
27 Apr 2007
Accepted
11 May 2007
First published
23 May 2007

Analyst, 2007,132, 633-634

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Single molecule level detection of allophycocyanin by surface enhanced resonance Raman scattering

C. D. McGuinness, A. M. Macmillan, J. Karolin, W. E. Smith, D. Graham, J. C. Pickup and D. J. S. Birch, Analyst, 2007, 132, 633 DOI: 10.1039/B706409H

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