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Issue 4, 2006
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Layers of opportunity: nanostructured polymer assemblies for the delivery of macromolecular therapeutics

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Abstract

Layer-by-layer approaches to the fabrication of nanostructured polymer assemblies have contributed to the design of thin films and composites of interest in a variety of areas. Here, we highlight recent contributions from our laboratory toward the design of multilayered assemblies that erode controllably and predictably in physiological environments and permit spatial and temporal control over the administration of macromolecular therapeutics, such as DNA. Our approach makes use of assemblies fabricated from hydrolytically degradable polyamines. We place this work in the context of recent progress from other laboratories and discuss new opportunities and connections that illustrate the potential of these layered assemblies as platforms for the controlled release of one or several therapeutic agents.

Graphical abstract: Layers of opportunity: nanostructured polymer assemblies for the delivery of macromolecular therapeutics

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Publication details

The article was received on 15 Dec 2005, accepted on 24 Jan 2006 and first published on 10 Feb 2006


Article type: Highlight
DOI: 10.1039/B517860F
Citation: Soft Matter, 2006,2, 269-273
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    Layers of opportunity: nanostructured polymer assemblies for the delivery of macromolecular therapeutics

    D. M. Lynn, Soft Matter, 2006, 2, 269
    DOI: 10.1039/B517860F

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