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Issue 3, 2006
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Biomimetic self-assembled nanofibers

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Peptide-amphiphiles, peptides to which a non-peptidic hydrophobic moiety has been added to the N or C terminal end, have been demonstrated to be a versatile method for simultaneously controlling nanostructure and chemical functionality. These amphiphiles are able to self-assemble, in a controlled fashion, into nanofibers with diameter between 6–10 nm and with length in excess of 1000 nm. At proper concentration these nanofibers form a viscoelastic gel capable of entrapping living cells and eliciting specific responses from them. Because of the flexibility of the display of chemical functionality on a controlled nanofibrous scaffold, applications for peptide-amphiphiles have been proposed including heterogeneous catalysis, nanoelectronics, drug delivery, and tissue engineering.

Graphical abstract: Biomimetic self-assembled nanofibers

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The article was received on 29 Nov 2005, accepted on 05 Jan 2006 and first published on 24 Jan 2006

Article type: Emerging Area
DOI: 10.1039/B516805H
Citation: Soft Matter, 2006,2, 177-181
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    Biomimetic self-assembled nanofibers

    H. Jun, S. E. Paramonov and J. D. Hartgerink, Soft Matter, 2006, 2, 177
    DOI: 10.1039/B516805H

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