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Issue 22, 2006
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Generating rapamycin analogues by directed biosynthesis: starter acid substrate specificity of mono-substituted cyclohexane carboxylic acids

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Abstract

We report a convenient synthesis of 4-fluorocyclohexanoic acid, and an insight into the rules governing acceptance of starter acid analogues in the precursor-directed biosynthesis of rapamycin.

Graphical abstract: Generating rapamycin analogues by directed biosynthesis: starter acid substrate specificity of mono-substituted cyclohexane carboxylic acids

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Publication details

The article was received on 05 Oct 2006, accepted on 05 Oct 2006 and first published on 16 Oct 2006


Article type: Communication
DOI: 10.1039/B614519C
Citation: Org. Biomol. Chem., 2006,4, 4071-4073
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    Generating rapamycin analogues by directed biosynthesis: starter acid substrate specificity of mono-substituted cyclohexane carboxylic acids

    R. J. M. Goss, S. E. Lanceron, N. J. Wise and S. J. Moss, Org. Biomol. Chem., 2006, 4, 4071
    DOI: 10.1039/B614519C

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