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Issue 21, 2006
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What I have learned by using chemical model systems to study biomolecular structure and interactions

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Abstract

Chemical model systems provide valuable insights into biomolecular structure and interactions by allowing researchers to simplify, isolate, and manipulate aspects of the complex molecular machinery of living systems. This perspective describes my laboratory's design, synthesis, and study of chemical model systems that fold and self-assemble like proteins and elucidates the insights that have come from studying these systems. Many of these studies have focused on protein β-sheets, which exhibit fascinating intra- and intermolecular interactions and play important roles in protein folding, aggregation, and molecular recognition.

Graphical abstract: What I have learned by using chemical model systems to study biomolecular structure and interactions

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Publication details

The article was received on 23 Jun 2006, accepted on 04 Sep 2006 and first published on 18 Sep 2006


Article type: Perspective
DOI: 10.1039/B608953B
Citation: Org. Biomol. Chem., 2006,4, 3869-3885
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    What I have learned by using chemical model systems to study biomolecular structure and interactions

    J. S. Nowick, Org. Biomol. Chem., 2006, 4, 3869
    DOI: 10.1039/B608953B

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