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Issue 19, 2006
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Chemical synthesis of picornaviral protein primers of RNA replication

Nicole M. A. J. Kriek,a  Nico J. Meeuwenoord,a  Hans van den Elst,a  Hans A. Heus,b  Gijsbert A. van der Marel*a  and  Dmitri V. Filippov*a 
Author affiliations

* Corresponding authors

a Leiden Institute of Chemistry, Leiden University, P.O. Box 9502, RA Leiden, The Netherlands
E-mail: filippov@chem.leidenuniv.nl, marel_g@chem.leidenuniv.nl
Fax: +31–71-5274307
Tel: +31–71-5274280

b Radboud University Nijmegen, Institute for Molecules and Materials, Laboratory of Biophysical Chemistry, Nijmegen, The Netherlands
E-mail: H.Heus@nmr.ru.nl

Abstract

Naturally occurring nucleopeptidic replication primers (VPg–pUpU) of poliovirus and coxsackie virus were chemically synthesized. The synthesis was accomplished via block-coupling of two minimally protected fragments of the target structures: a short RNA-nucleopeptide and a longer peptide segment containing diverse side-chain functionalities. The synthetic VPg–pUpU of coxsackie virus was characterized by NMR spectroscopy.

Graphical abstract: Chemical synthesis of picornaviral protein primers of RNA replication

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Publication details

The article was received on 15 Jun 2006, accepted on 10 Aug 2006 and first published on 30 Aug 2006


Article type: Paper
DOI: 10.1039/B608544J
Citation: Org. Biomol. Chem., 2006,4, 3576-3586
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    Chemical synthesis of picornaviral protein primers of RNA replication

    N. M. A. J. Kriek, N. J. Meeuwenoord, H. van den Elst, H. A. Heus, G. A. van der Marel and D. V. Filippov, Org. Biomol. Chem., 2006, 4, 3576
    DOI: 10.1039/B608544J

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