Issue 17, 2006
From the journal:

Organic & Biomolecular Chemistry

Synthesis and anticancer activity studies of α-aminoalkylated conjugated nitroalkenes†

Namrata Rastogi,a   Renu Mohan,b   Dulal Panda,*b   Shaikh M. Mobinc  and  Irishi N. N. Namboothiri*a  

* Corresponding authors

a Department of Chemistry, Indian Institute of Technology, Bombay, Mumbai 400 076, India
E-mail: irishi@iitb.ac.in

b School of Biosciences and Bioengineering, Indian Institute of Technology, Bombay, Mumbai 400 076, India
E-mail: panda@btc.iitb.ac.in

c National Single Crystal X-ray Diffraction Facility, Indian Institute of Technology, Bombay, Mumbai 400 076, India

Abstract

Novel α-aminoalkylated conjugated nitroalkenes which inhibit human cervical cancer (HeLa) cell proliferation by binding to tubulin were synthesized by imidazole/LiCl-mediated reaction of conjugated nitroalkenes with N-tosylimines.

Graphical abstract: Synthesis and anticancer activity studies of α-aminoalkylated conjugated nitroalkenes

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Article information

DOI
https://doi.org/10.1039/B607537A
Article type
Communication
Submitted
26 May 2006
Accepted
19 Jul 2006
First published
28 Jul 2006

Org. Biomol. Chem., 2006,4, 3211-3214

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Synthesis and anticancer activity studies of α-aminoalkylated conjugated nitroalkenes

N. Rastogi, R. Mohan, D. Panda, S. M. Mobin and I. N. N. Namboothiri, Org. Biomol. Chem., 2006, 4, 3211 DOI: 10.1039/B607537A

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