Issue 11, 2006
From the journal:

Organic & Biomolecular Chemistry

Enantioselective construction of quaternary carbon centre catalysed by bifunctional organocatalyst†

Tian-Yu Liu,a   Jun Long,a   Bang-Jing Li,b   Lin Jiang,a   Rui Li,b   Yong Wu,a   Li-Sheng Dingb  and  Ying-Chun Chen*a  

* Corresponding authors

a Key Laboratory of Drug-Targeting of Education Ministry and Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu, China
E-mail: ycchenhuaxi@yahoo.com.cn.
Fax: 86 28 85502609
Tel: 86 28 85502609

b Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, China

Abstract

The bifunctional thiourea–tertiary amine derivatives of simple chiral diamines serve as highly enantioselective catalysts for the Michael addition of α-substituted cyanoacetates to vinyl sulfones, giving an efficient protocol for the construction of an all-carbon substituted quaternary stereocentre.

Graphical abstract: Enantioselective construction of quaternary carbon centre catalysed by bifunctional organocatalyst

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Article information

DOI
https://doi.org/10.1039/B605871J
Article type
Communication
Submitted
25 Apr 2006
Accepted
02 May 2006
First published
09 May 2006

Org. Biomol. Chem., 2006,4, 2097-2099

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Enantioselective construction of quaternary carbon centre catalysed by bifunctional organocatalyst

T. Liu, J. Long, B. Li, L. Jiang, R. Li, Y. Wu, L. Ding and Y. Chen, Org. Biomol. Chem., 2006, 4, 2097 DOI: 10.1039/B605871J

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