Jump to main content
Jump to site search
Publishing
Advanced

Issue 17, 2006
Previous Article Next Article

Phenol quaternary ammonium derivatives: charge and linker effect on their DNA photo-inducible cross-linking abilities

Yang Song,a  Tian Tian,a  Ping Wang,a  Hanping He,a  Wulue Liu,a  Xiang Zhou,*ab  Xiaoping Cao,d  Xiao-Lian Zhang*c  and  Xin Zhou*e 
Author affiliations

* Corresponding authors

a College of Chemistry and Molecular Sciences, Wuhan University, Hubei, P. R. of China
E-mail: xzhou@whu.edu.cn

b Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Peking University, Beijing, P. R. of China

c College of Medicine, Wuhan University, Hubei, P. R. of China

d National Applied Organic Chemistry, Lanzhou University, Gansu Lanzhou, P. R. of China

e Zhongnan Hospital, Wuhan University, Hubei, P. R. of China

Abstract

We report here that phenol derivatives with two and four quaternary ammoniums were synthesized and their abilities to bind and cross-link DNA were investigated. Thermal denaturizing studies indicated that derivatives possess similar DNA binding abilities and gel electrophoresis revealed that more charges (series B) and electronic donation substitute linkers (like –S–) dramatically increase the DNA cross-linking abilities.

Graphical abstract: Phenol quaternary ammonium derivatives: charge and linker effect on their DNA photo-inducible cross-linking abilities

Back to tab navigation
Download options Please wait...

Supplementary files

Publication details

The article was received on 29 Mar 2006, accepted on 07 Jul 2006 and first published on 01 Aug 2006


Article type: Paper
DOI: 10.1039/B604552A
Citation: Org. Biomol. Chem., 2006,4, 3358-3366
  •   Request permissions

    Phenol quaternary ammonium derivatives: charge and linker effect on their DNA photo-inducible cross-linking abilities

    Y. Song, T. Tian, P. Wang, H. He, W. Liu, X. Zhou, X. Cao, X. Zhang and X. Zhou, Org. Biomol. Chem., 2006, 4, 3358
    DOI: 10.1039/B604552A

    If you are not the author of this article and you wish to reproduce material from it in a third party non-RSC publication you must formally request permission using RightsLink. Go to our Instructions for using RightsLink page for details.

    Authors contributing to RSC publications (journal articles, books or book chapters) do not need to formally request permission to reproduce material contained in this article provided that the correct acknowledgement is given with the reproduced material.

    Reproduced material should be attributed as follows:

    • For reproduction of material from NJC:
      Reproduced from Ref. XX with permission from the Centre National de la Recherche Scientifique (CNRS) and The Royal Society of Chemistry.
    • For reproduction of material from PCCP:
      Reproduced from Ref. XX with permission from the PCCP Owner Societies.
    • For reproduction of material from PPS:
      Reproduced from Ref. XX with permission from the European Society for Photobiology, the European Photochemistry Association, and The Royal Society of Chemistry.
    • For reproduction of material from all other RSC journals and books:
      Reproduced from Ref. XX with permission from The Royal Society of Chemistry.

    If the material has been adapted instead of reproduced from the original RSC publication "Reproduced from" can be substituted with "Adapted from".

    In all cases the Ref. XX is the XXth reference in the list of references.

    If you are the author of this article you do not need to formally request permission to reproduce figures, diagrams etc. contained in this article in third party publications or in a thesis or dissertation provided that the correct acknowledgement is given with the reproduced material.

    Reproduced material should be attributed as follows:

    • For reproduction of material from NJC:
      [Original citation] - Reproduced by permission of The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC
    • For reproduction of material from PCCP:
      [Original citation] - Reproduced by permission of the PCCP Owner Societies
    • For reproduction of material from PPS:
      [Original citation] - Reproduced by permission of The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC
    • For reproduction of material from all other RSC journals:
      [Original citation] - Reproduced by permission of The Royal Society of Chemistry

    If you are the author of this article you still need to obtain permission to reproduce the whole article in a third party publication with the exception of reproduction of the whole article in a thesis or dissertation.

    Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.

Search articles by author

Spotlight

Advertisements