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Design, synthesis and evaluation of furanocoumarin monomers as inhibitors of CYP3A4

E. C. Row,a   S. A. Brown,b   A. V. Stachulskib and   M. S. Lennard*a  
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a
Academic Unit of Clinical Pharmacology, Pharmacokinetics and Pharmacogenetics Group, University of Sheffield, M Floor, Royal Hallamshire Hospital, Sheffield, U.K.
E-mail: m.s.lennard@sheffield.ac.uk ;
Tel: +44 114 2712578
b
SAFC Pharma (formerly Ultrafine), Synergy House, Manchester Science Park, Manchester, U.K.
Org. Biomol. Chem., 2006,4, 1604-1610

DOI: 10.1039/B601096B
Received 23 Jan 2006, Accepted 23 Feb 2006
First published online 20 Mar 2006
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