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Issue 8, 2006
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Interception of quorum sensing in Staphylococcus aureus: a new niche for peptidomimetics

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Abstract

Pathogenesis in Staphylococcus aureus is dependent on local cell density and is regulated in part by small macrocyclic peptides. Natural and artificial peptide inhibitors of this quorum sensing response have been synthesized and evaluated in structure–activity relationship studies. These investigations have illuminated the quorum sensing mechanism and set the stage for the design of biostable, peptidomimetic inhibitors that could be developed ultimately as therapeutics.

Graphical abstract: Interception of quorum sensing in Staphylococcus aureus: a new niche for peptidomimetics

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Publication details

The article was received on 13 Dec 2005, accepted on 20 Feb 2006 and first published on 16 Mar 2006


Article type: Emerging Area
DOI: 10.1039/B517681F
Citation: Org. Biomol. Chem., 2006,4, 1441-1445
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    Interception of quorum sensing in Staphylococcus aureus: a new niche for peptidomimetics

    B. C. Gorske and H. E. Blackwell, Org. Biomol. Chem., 2006, 4, 1441
    DOI: 10.1039/B517681F

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