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Issue 16, 2006
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New propranolol analogues: binding and chiral discrimination by cellobiohydrolase Cel7A

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Abstract

Novel propranolol analogues have been designed and synthesised and their enantioselective binding to the cellulose degrading enzyme, Cel7A, has been evaluated. Affinity and enantioselectivity have been determined by capillary electrophoresis experiments. Ligands with significantly improved affinity and selectivity have been obtained and an analysis of the results has led to insights concerning the relation between the changes in ligand structure and selectivity as well as affinity to the protein.

Graphical abstract: New propranolol analogues: binding and chiral discrimination by cellobiohydrolase Cel7A

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Publication details

The article was received on 20 Apr 2006, accepted on 23 Jun 2006 and first published on 19 Jul 2006


Article type: Paper
DOI: 10.1039/B605603B
Citation: Org. Biomol. Chem., 2006,4, 3067-3076
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    New propranolol analogues: binding and chiral discrimination by cellobiohydrolase Cel7A

    A. Fagerström, M. Nilsson, U. Berg and R. Isaksson, Org. Biomol. Chem., 2006, 4, 3067
    DOI: 10.1039/B605603B

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