Issue 12, 2006
From the journal:

Organic & Biomolecular Chemistry

Development of a linear type of low molecular weight CXCR4 antagonists based on T140 analogs†

Hirokazu Tamamura,*a   Hiroshi Tsutsumi,a   Hiroyuki Masuno,a   Satoko Mizokami,b   Kenichi Hiramatsu,b   Zixuan Wang,c   John O. Trent,d   Hideki Nakashima,e   Naoki Yamamoto,fg   Stephen C. Peiperc  and  Nobutaka Fujii*b  

* Corresponding authors

a Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Chiyoda-ku, Tokyo 101-0062, Japan
E-mail: tamamura.mr@tmd.ac.jp
Fax: 81 3 5280 8039
Tel: 81 3 5280 8036

b Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan
E-mail: nfujii@pharm.kyoto-u.ac.jp
Fax: 81 75 753 4570
Tel: 81 75 753 4551

c Medical College of Georgia, Augusta, GA 30912, USA

d James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA

e St. Marianna University, School of Medicine, Miyamae-ku, Kawasaki 216-8511, Japan

f AIDS Research Center, National Institute of Infectious Diseases, Shinjuku-ku, Tokyo 162-8640, Japan

g Graduate School, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo 113-8519, Japan

Abstract

A linear type of several low molecular weight CXCR4 antagonists were developed based on T140 analogs, which were previously found to be strong CXCR4 antagonists that block X4-HIV-1 entry and have inhibitory activities against cancer metastasis/progression and rheumatoid arthritis.

Graphical abstract: Development of a linear type of low molecular weight CXCR4 antagonists based on T140 analogs

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Article information

DOI
https://doi.org/10.1039/B603818B
Article type
Communication
Submitted
14 Mar 2006
Accepted
24 Apr 2006
First published
12 May 2006

Org. Biomol. Chem., 2006,4, 2354-2357

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Development of a linear type of low molecular weight CXCR4 antagonists based on T140 analogs

H. Tamamura, H. Tsutsumi, H. Masuno, S. Mizokami, K. Hiramatsu, Z. Wang, J. O. Trent, H. Nakashima, N. Yamamoto, S. C. Peiper and N. Fujii, Org. Biomol. Chem., 2006, 4, 2354 DOI: 10.1039/B603818B

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