Issue 11, 2006
From the journal:

Organic & Biomolecular Chemistry

The synthesis of tethered ligand dimers for PPARγ–RXR protein heterodimers

Debra L. Mohler*ab  and  Gang Shena  

* Corresponding authors

a Department of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia, USA

b Department of Chemistry, James Madison University, MSC 4501, Harrisonburg, Virginia, USA
E-mail: mohlerdl@jmu.edu
Fax: 540-568-7938
Tel: 540-568-8803

Abstract

Heterodimeric compounds based on tethering the PPARγ agonist Rosiglitazone to the RXR ligand Targretin have been prepared.

Graphical abstract: The synthesis of tethered ligand dimers for PPARγ–RXR protein heterodimers

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Article information

DOI
https://doi.org/10.1039/B600848H
Article type
Communication
Submitted
19 Jan 2006
Accepted
24 Apr 2006
First published
04 May 2006

Org. Biomol. Chem., 2006,4, 2082-2087

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The synthesis of tethered ligand dimers for PPARγ–RXR protein heterodimers

D. L. Mohler and G. Shen, Org. Biomol. Chem., 2006, 4, 2082 DOI: 10.1039/B600848H

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