Issue 1, 2006

The small peptide-catalyzed direct asymmetric aldol reaction in water

Abstract

Simple modular di- and tripeptides with a primary amine at the N-terminus catalyze the aqueous asymmetric aldol reaction between unmodified ketones and aldehydes to furnish the corresponding β-hydroxy ketones with up to 86% ee in water and 99% ee in aqueos media.

Graphical abstract: The small peptide-catalyzed direct asymmetric aldol reaction in water

Supplementary files

Article information

Article type
Communication
Submitted
28 Sep 2005
Accepted
08 Nov 2005
First published
22 Nov 2005

Org. Biomol. Chem., 2006,4, 38-40

The small peptide-catalyzed direct asymmetric aldol reaction in water

P. Dziedzic, W. Zou, J. Háfren and A. Córdova, Org. Biomol. Chem., 2006, 4, 38 DOI: 10.1039/B515880J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements