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Issue 1, 2006
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The small peptide-catalyzed direct asymmetric aldol reaction in water

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Abstract

Simple modular di- and tripeptides with a primary amine at the N-terminus catalyze the aqueous asymmetric aldol reaction between unmodified ketones and aldehydes to furnish the corresponding β-hydroxy ketones with up to 86% ee in water and 99% ee in aqueos media.

Graphical abstract: The small peptide-catalyzed direct asymmetric aldol reaction in water

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Publication details

The article was received on 28 Sep 2005, accepted on 08 Nov 2005 and first published on 22 Nov 2005


Article type: Communication
DOI: 10.1039/B515880J
Citation: Org. Biomol. Chem., 2006,4, 38-40
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    The small peptide-catalyzed direct asymmetric aldol reaction in water

    P. Dziedzic, W. Zou, J. Háfren and A. Córdova, Org. Biomol. Chem., 2006, 4, 38
    DOI: 10.1039/B515880J

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