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Issue 12, 2006
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Molecular anchors—mimicking metabolic processes in thiol analysis

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Abstract

The interaction between various novel naphthoquinones and glutathione was explored using a variety of electrochemical techniques. An adamantane derivatised quinone was found to adsorb strongly to carbon surfaces providing a robust film possessing a distinct and consistent voltammetric profile which is markedly different from solution based species. The anodic peak process was found to respond to increasing additions of glutathione and the analytical merits have been assessed. In contrast to conventional thiolquinone electrochemistry, the detection pathway involves the solubilisation and removal of the hydrophobic quinone derivative through conjugation with glutathione. The peak potential (+0.2 V vs. Ag/AgCl) is such that an unambiguous response to glutathione can be achieved in the presence of a significant excess (1 mM) of common physiological components.

Graphical abstract: Molecular anchors—mimicking metabolic processes in thiol analysis

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Publication details

The article was received on 08 Aug 2006, accepted on 08 Sep 2006 and first published on 26 Sep 2006


Article type: Paper
DOI: 10.1039/B611471G
Citation: New J. Chem., 2006,30, 1718-1724
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    Molecular anchors—mimicking metabolic processes in thiol analysis

    R. B. Smith, C. Canton, N. S. Lawrence, C. Livingstone and J. Davis, New J. Chem., 2006, 30, 1718
    DOI: 10.1039/B611471G

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