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Issue 11, 2006
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Fabrication of non-biofouling polyethylene glycol micro- and nanochannels by ultraviolet-assisted irreversible sealing

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Abstract

We present a simple and widely applicable method to fabricate micro- and nanochannels comprised entirely of crosslinked polyethylene glycol (PEG) by using UV-assisted irreversible sealing to bond partially crosslinked PEG surfaces. The method developed here can be used to form channels as small as ∼50 nm in diameter without using a sophisticated experimental setup. The manufactured channel is a homogeneous conduit made completely from non-biofouling PEG, exhibits robust sealing with minimal swelling and can be used without additional surface modification chemistries, thus significantly enhancing reliability and durability of microfluidic devices. Furthermore, we demonstrate simple analytical assays using PEG microchannels combined with patterned arrays of supported lipid bilayers (SLBs) to detect ligand (biotin)–receptor (streptavidin) interactions.

Graphical abstract: Fabrication of non-biofouling polyethylene glycol micro- and nanochannels by ultraviolet-assisted irreversible sealing

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Publication details

The article was received on 21 Jul 2006, accepted on 29 Aug 2006 and first published on 14 Sep 2006


Article type: Paper
DOI: 10.1039/B610503C
Citation: Lab Chip, 2006,6, 1432-1437
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    Fabrication of non-biofouling polyethylene glycol micro- and nanochannels by ultraviolet-assisted irreversible sealing

    P. Kim, H. E. Jeong, A. Khademhosseini and K. Y. Suh, Lab Chip, 2006, 6, 1432
    DOI: 10.1039/B610503C

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