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Issue 8, 2006
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Photopolymerized check valve and its integration into a pneumatic pumping system for biocompatible sample delivery

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Abstract

In this paper, we present a simple check valve whose operation mimics that of venous valves. Our check valve has a mono-leaflet and is constructed via an in situ fabrication method inside the PDMS platform. For the smooth operation of the valve's leaflet, the elasticity and the shape of the leaflet and the lubrication between the leaflet and the channel surface are important. We used 4-hydroxybutyl acrylate (4-HBA) as an elastic and photopolymerizable leaflet material. We mixed the triton X-100 with the 4-HBA pre-polymer solution for the adequate lubrication of the leaflet. We constructed the micro-pumping system by combining two venous-like check valves with an oscillating polymeric diaphragm driven by pneumatic force, and measured the flow rate according to the change of pumping frequency. We also investigated the pump's feasibility as a delivery system of biocompatible materials by using mouse embryo fibroblast cells.

Graphical abstract: Photopolymerized check valve and its integration into a pneumatic pumping system for biocompatible sample delivery

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Publication details

The article was received on 16 May 2006, accepted on 19 May 2006 and first published on 15 Jun 2006


Article type: Technical Note
DOI: 10.1039/B606918E
Citation: Lab Chip, 2006,6, 1091-1094
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    Photopolymerized check valve and its integration into a pneumatic pumping system for biocompatible sample delivery

    J. Kim, J. Baek, K. Lee, Y. Park, K. Sun, T. Lee and S. Lee, Lab Chip, 2006, 6, 1091
    DOI: 10.1039/B606918E

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