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Issue 7, 2006
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Simulating molecular shuttle movements: Towards computer-aided design of nanoscale transport systems

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Abstract

Molecular shuttles based on the motor protein kinesin and microtubule filaments have the potential to extend the lab-on-a-chip paradigm to nanofluidics by enabling the active, directed and selective transport of molecules and nanoparticles. Based on experimentally determined parameters, in particular the trajectory persistence length of a microtubule gliding on surface-adhered kinesin motors, we developed a Monte-Carlo simulation, which models the transport properties of guiding structures, such as channels, rectifiers and concentrators, and reproduces the properties of several experimentally realized systems. Our tool facilitates the rational design of individual guiding structures as well as whole networks, and can be adapted to the simulation of other nanoscale transport systems.

Graphical abstract: Simulating molecular shuttle movements: Towards computer-aided design of nanoscale transport systems

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Publication details

The article was received on 06 Feb 2006, accepted on 15 May 2006 and first published on 31 May 2006


Article type: Paper
DOI: 10.1039/B601754A
Citation: Lab Chip, 2006,6, 881-885
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    Simulating molecular shuttle movements: Towards computer-aided design of nanoscale transport systems

    T. Nitta, A. Tanahashi, M. Hirano and H. Hess, Lab Chip, 2006, 6, 881
    DOI: 10.1039/B601754A

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