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Issue 3, 2006
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Microfluidic sorting system based on optical waveguide integration and diode laser bar trapping

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Abstract

Effective methods for manipulating, isolating and sorting cells and particles are essential for the development of microfluidic-based life science research and diagnostic platforms. We demonstrate an integrated optical platform for cell and particle sorting in microfluidic structures. Fluorescent-dyed particles are excited using an integrated optical waveguide network within micro-channels. A diode-bar optical trapping scheme guides the particles across the waveguide/micro-channel structures and selectively sorts particles based upon their fluorescent signature. This integrated detection and separation approach streamlines microfluidic cell sorting and minimizes the optical and feedback complexity commonly associated with extant platforms.

Graphical abstract: Microfluidic sorting system based on optical waveguide integration and diode laser bar trapping

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Publication details

The article was received on 08 Sep 2005, accepted on 05 Jan 2006 and first published on 20 Jan 2006


Article type: Paper
DOI: 10.1039/B512576F
Citation: Lab Chip, 2006,6, 422-426
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    Microfluidic sorting system based on optical waveguide integration and diode laser bar trapping

    R. W. Applegate Jr., J. Squier, T. Vestad, J. Oakey, D. W. M. Marr, P. Bado, M. A. Dugan and A. A. Said, Lab Chip, 2006, 6, 422
    DOI: 10.1039/B512576F

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