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Issue 8, 2006
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Compact fluorescence detection using in-fiber microchannels—its potential for lab-on-a-chip applications

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Abstract

This paper reports a compact and practical fluorescence sensor using an in-fiber microchannel. A blue LED, a multimode PMMA or silica fiber and a mini-PMT were used as an excitation source, a light guide and a fluorescence detector, respectively. Microfluidic channels of 100 µm width and 210µm depth were fabricated in the optical fibers using a direct-write CO2 laser system. The experimental results show that the sensor has high sensitivity, able to detect 0.005 µg L−1 of fluorescein in the PBS solution, and the results are reproducible. The results also show that the silica fiber sensor has better sensitivity than that of the PMMA fiber sensor. This could be due to the fouling effect of the frosty layer formed at the microchannel made within the PMMA fiber. It is believed that this fiber sensor has the potential to be integrated into microfluidic chips for lab-on-a-chip applications.

Graphical abstract: Compact fluorescence detection using in-fiber microchannels—its potential for lab-on-a-chip applications

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Publication details

The article was received on 05 Jan 2006, accepted on 02 Jun 2006 and first published on 28 Jun 2006


Article type: Technical Note
DOI: 10.1039/B607834F
Citation: Lab Chip, 2006,6, 1095-1098
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    Compact fluorescence detection using in-fiber microchannels—its potential for lab-on-a-chip applications

    R. Irawan, C. M. Tay, S. C. Tjin and C. Y. Fu, Lab Chip, 2006, 6, 1095
    DOI: 10.1039/B607834F

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