Issue 6, 2006
From the journal:

Lab on a Chip

Centrifugal extraction of plasma from whole blood on a rotating disk

Stefan Haeberle,*a   Thilo Brenner,a   Roland Zengerleab  and  Jens Ducréeab  

* Corresponding authors

a Laboratory for MEMS Applications, Department of Microsystems Engineering (IMTEK), University of Freiburg, Georges-Koehler-Allee 106, D-79110 Freiburg, Germany

b HSG-IMIT – Institute of Micromachining and Information Technology, Wilhelm-Schickard-Straße 10, D-78052 Villingen-Schwenningen, Germany
E-mail: haeberle@imtek.de
Fax: +49 761 203 7539
Tel: +49 761 203 7476

Abstract

We present a centrifugal process for the extraction of plasma from sediment by a decanting structure, terminating with metered plasma which is readily available for subsequent on-disk processing. Our technique supplies 2 µl plasma from 5 µl of whole blood at moderate spinning frequencies of 40 Hz within 20 s, only. The residual cell concentration in the purified plasma amounts to less than 0.11%, independent of the frequency of rotation. A capillary duct connects the extracted plasma to subsequent on-disk processing units.

Graphical abstract: Centrifugal extraction of plasma from whole blood on a rotating disk

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Article information

DOI
https://doi.org/10.1039/B604145K
Article type
Paper
Submitted
21 Mar 2006
Accepted
30 Mar 2006
First published
13 Apr 2006

Lab Chip, 2006,6, 776-781

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Centrifugal extraction of plasma from whole blood on a rotating disk

S. Haeberle, T. Brenner, R. Zengerle and J. Ducrée, Lab Chip, 2006, 6, 776 DOI: 10.1039/B604145K

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