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Issue 28, 2006
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Optimisation of the synthesis and modification of CdTe quantum dots for enhanced live cell imaging

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Abstract

We report the preparation and luminescence enhancement of thioglycolic acid (TGA) stabilised CdTe quantum dots (QDs) for use as live cell imaging tools in THP-1 macrophage cells. Short irradiating times utilising a high powered Hg lamp resulted in increases in luminescence efficiencies of up to ∼40% and permit significantly enhanced live imaging of the THP-1 cellular components. It was found that the TGA-stabilised QDs traverse the cell membrane, illuminating the cytoplasm and decorating the nuclear membrane. These studies highlight the potential use of photoetched CdTe QDs as probes for specific in vitro labelling.

Graphical abstract: Optimisation of the synthesis and modification of CdTe quantum dots for enhanced live cell imaging

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Publication details

The article was received on 13 Apr 2006, accepted on 23 May 2006 and first published on 12 Jun 2006


Article type: Paper
DOI: 10.1039/B605333E
Citation: J. Mater. Chem., 2006,16, 2896-2902
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    Optimisation of the synthesis and modification of CdTe quantum dots for enhanced live cell imaging

    S. J. Byrne, S. A. Corr, T. Y. Rakovich, Y. K. Gun'ko, Y. P. Rakovich, J. F. Donegan, S. Mitchell and Y. Volkov, J. Mater. Chem., 2006, 16, 2896
    DOI: 10.1039/B605333E

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