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Issue 5, 2006
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Functionalization of mesoporous materials with long alkyl chains as a strategy for controlling drug delivery pattern

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Abstract

Mesoporous silica SBA-15 was prepared to evaluate its effectiveness as a matrix for the controlled delivery of macrolide-type antibiotics. Two types of material were used to evaluate the delivery: calcined samples and samples functionalized with octyltrimethoxysilane and octadecyltrimethoxysilane. The samples were charged with the macrolide antibiotic erythromycin and the release assays were carried out in vitro. It has been observed that the release rate decreases as the population of hydrophobic –CH2 moieties in the host increases.

Graphical abstract: Functionalization of mesoporous materials with long alkyl chains as a strategy for controlling drug delivery pattern

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Publication details

The article was received on 05 Jul 2005, accepted on 31 Oct 2005 and first published on 18 Nov 2005


Article type: Paper
DOI: 10.1039/B510101H
Citation: J. Mater. Chem., 2006,16, 462-466
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    Functionalization of mesoporous materials with long alkyl chains as a strategy for controlling drug delivery pattern

    J. C. Doadrio, E. M. B. Sousa, I. Izquierdo-Barba, A. L. Doadrio, J. Perez-Pariente and M. Vallet-Regí, J. Mater. Chem., 2006, 16, 462
    DOI: 10.1039/B510101H

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