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Issue 4, 2006
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Size characterisation of Au nanoparticles by ICP-MS coupling techniques

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Abstract

In modern nanotechnology the properties of nanoparticles (NPs) in different application fields is mainly dependent on their size and their size distribution. This paper aims to develop a reliable method for the size characterisation of Au NPs. Basing on the combination of two different separation techniques (liquid chromatography and gel electrophoresis), coupled on-line to inductively coupled plasma-mass spectrometry (ICP-MS), we study the separation of Au NP standards. Separations by liquid chromatography show size dependent retention behaviour with good reproducibility (RSD < 1%). The results are compared with complementary methods like dynamic light scattering (DLS) and transmission electron microscopy (TEM) and show good agreement. Furthermore, the on-line coupling of gel electrophoresis and ICP-MS results in a distinct peak tailing for the analysis of these NPs, which is found to be related to the chemical structure of the NP’s surface. It can be demonstrated that NPs with a covalently bound surface do behave in a different way.

Graphical abstract: Size characterisation of Au nanoparticles by ICP-MS coupling techniques

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Publication details

The article was received on 18 Aug 2005, accepted on 17 Feb 2006 and first published on 09 Mar 2006


Article type: Technical Note
DOI: 10.1039/B511705D
Citation: J. Anal. At. Spectrom., 2006,21, 431-434
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    Size characterisation of Au nanoparticles by ICP-MS coupling techniques

    A. Helfrich, W. Brüchert and J. Bettmer, J. Anal. At. Spectrom., 2006, 21, 431
    DOI: 10.1039/B511705D

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