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Issue 9, 2006
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Continuous kinetic resolution catalysed by cross-linked enzyme aggregates, ‘CLEAs’, in supercritical CO2

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Abstract

We report the use of cross-linked enzyme aggregates (CLEAs®) to catalyse the kinetic resolution of tetralol and 1-phenylethanol in a continuous supercritical carbon dioxide (scCO2) system. We describe the performance of the CLEA from Candida antarctica lipase B (CALB) and compare this to the catalytic activity of Novozym 435 (CALB immobilised on a macroporous acrylic resin). In addition, we report a two-stage reaction with the kinetic resolution of 1-phenylethanol performed in series with the metal (Pd) catalysed hydrogenation of acetophenone. Reactions performed in series have a potential economic advantage as the second, and subsequent reactions do not require additional expenditure of energy for re-pressurization of solvent.

Graphical abstract: Continuous kinetic resolution catalysed by cross-linked enzyme aggregates, ‘CLEAs’, in supercritical CO2

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Publication details

The article was received on 03 Apr 2006, accepted on 23 Jun 2006 and first published on 17 Jul 2006


Article type: Paper
DOI: 10.1039/B604738F
Citation: Green Chem., 2006,8, 816-821
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    Continuous kinetic resolution catalysed by cross-linked enzyme aggregates, ‘CLEAs’, in supercritical CO2

    H. R. Hobbs, B. Kondor, P. Stephenson, R. A. Sheldon, N. R. Thomas and M. Poliakoff, Green Chem., 2006, 8, 816
    DOI: 10.1039/B604738F

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