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Issue 6, 2006
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Strategies for increasing the sensitivity of gadolinium based MRI contrast agents

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Abstract

Gadolinium(III) complexes are often used in clinical MRI to increase contrast by selectively relaxing the water molecules near the complex. There is a desire to improve the sensitivity (relaxivity) of these contrast agents in order to detect molecular targets. This tutorial review describes the molecular factors that contribute to relaxivity and illustrates with recent examples how these can be optimized. It may be of interest to senior undergraduates and more advanced researchers interested in lanthanide chemistry, biophysics, and/or molecular imaging.

Graphical abstract: Strategies for increasing the sensitivity of gadolinium based MRI contrast agents

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Publication details

The article was received on 10 Apr 2006 and first published on 03 May 2006


Article type: Tutorial Review
DOI: 10.1039/B510982P
Citation: Chem. Soc. Rev., 2006,35, 512-523
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    Strategies for increasing the sensitivity of gadolinium based MRI contrast agents

    P. Caravan, Chem. Soc. Rev., 2006, 35, 512
    DOI: 10.1039/B510982P

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