Jump to main content
Jump to site search

Issue 3, 2006
Previous Article Next Article

Design and application of linked-BINOL chiral ligands in bifunctional asymmetric catalysis

Author affiliations

Abstract

The design and application of linked-BINOLs investigated in our group are reviewed. Linked-BINOLs are a kind of semi-crown ether, thus they are flexible and applicable to metals having various ionic radii (Ga3+, Li+, Zn2+, In3+, La3+, and Y3+). The flexible linker segment, containing a coordinative heteroatom, has a crucial role in the construction of a unique and effective chiral environment that is not accessible from BINOL itself. Applications of linked-BINOLs to an epoxide opening reaction, Michael reactions, a direct aldol reaction, direct Michael reactions of a hydroxyketone, and direct Mannich-type reactions of hydroxyketones and N-acylpyrrole are described.

Graphical abstract: Design and application of linked-BINOL chiral ligands in bifunctional asymmetric catalysis

Back to tab navigation

Publication details

The article was received on 23 Nov 2005 and first published on 09 Feb 2006


Article type: Tutorial Review
DOI: 10.1039/B506346A
Citation: Chem. Soc. Rev., 2006,35, 269-279
  •   Request permissions

    Design and application of linked-BINOL chiral ligands in bifunctional asymmetric catalysis

    M. Shibasaki and S. Matsunaga, Chem. Soc. Rev., 2006, 35, 269
    DOI: 10.1039/B506346A

Search articles by author

Spotlight

Advertisements