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Issue 4, 2006
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Application of alicyclic β-amino acids in peptide chemistry

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Abstract

The self-organizing β-peptides have attracted considerable interest in the fields of foldamer chemistry and biochemistry. These compounds exhibit various stable secondary structure motifs that can be exploited to construct biologically active substances and nanostructured tertiary structures. The secondary structures can be controlled via the β-amino acid sequence, and cyclic β-amino acid residues play a crucial role in the design. The most important procedures for the preparation of cyclic β-amino acid monomers and peptides are discussed in this tutorial review. Besides the secondary structure design principles, the methods of folded structure detection are surveyed.

Graphical abstract: Application of alicyclic β-amino acids in peptide chemistry

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Publication details

The article was received on 05 Nov 2005 and first published on 19 Jan 2006


Article type: Tutorial Review
DOI: 10.1039/B501173F
Citation: Chem. Soc. Rev., 2006,35, 323-334
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    Application of alicyclic β-amino acids in peptide chemistry

    F. Fülöp, T. A. Martinek and G. K. Tóth, Chem. Soc. Rev., 2006, 35, 323
    DOI: 10.1039/B501173F

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