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Issue 46, 2006
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A flow reactor process for the synthesis of peptides utilizing immobilized reagents, scavengers and catch and release protocols

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Abstract

A general flow process for the multi-step assembly of peptides has been developed and this procedure has been used to successfully construct a series of Boc, Cbz and Fmoc N-protected dipeptides in excellent yields and purities, including an extension of the method to enable the preparation of a tripeptide derivative.

Graphical abstract: A flow reactor process for the synthesis of peptides utilizing immobilized reagents, scavengers and catch and release protocols

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Publication details

The article was received on 24 Aug 2006, accepted on 19 Sep 2006 and first published on 03 Oct 2006


Article type: Communication
DOI: 10.1039/B612197G
Citation: Chem. Commun., 2006, 4835-4837
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    A flow reactor process for the synthesis of peptides utilizing immobilized reagents, scavengers and catch and release protocols

    I. R. Baxendale, S. V. Ley, C. D. Smith and G. K. Tranmer, Chem. Commun., 2006, 4835
    DOI: 10.1039/B612197G

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