Issue 39, 2006
From the journal:

Chemical Communications

Enantioselective rhodium-catalyzed addition of arylboronic acids to trifluoromethyl ketones†

Sébastien L. X. Martina,a   Richard B. C. Jagt,a   Johannes G. de Vries,*b   Ben L. Feringa*a  and  Adriaan J. Minnaard*a  

* Corresponding authors

a Department of Organic and Molecular Inorganic Chemistry, Stratingh Institute, University of Groningen, Nijenborgh 4, Groningen, The Netherlands
E-mail: b.l.feringa@rug.nl, a.j.minnaard@rug.nl

b DSM Pharmaceutical Products - Advanced Synthesis & Catalysis, P.O. Box 18, Geleen, The Netherlands
E-mail: hans-jg.vries-de@dsm.com

Abstract

The catalytic asymmetric 1,2-addition of a series of arylboronic acids to 2,2,2-trifluoroacetophenones is described with high isolated yields (up to 96%) and good enantioselectivities (up to 83% ee) using a rhodium(I)/phosphoramidite catalyst.

Graphical abstract: Enantioselective rhodium-catalyzed addition of arylboronic acids to trifluoromethyl ketones

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Article information

DOI
https://doi.org/10.1039/B609453H
Article type
Communication
Submitted
04 Jul 2006
Accepted
08 Aug 2006
First published
22 Aug 2006

Chem. Commun., 2006, 4093-4095

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Enantioselective rhodium-catalyzed addition of arylboronic acids to trifluoromethyl ketones

S. L. X. Martina, R. B. C. Jagt, J. G. de Vries, B. L. Feringa and A. J. Minnaard, Chem. Commun., 2006, 4093 DOI: 10.1039/B609453H

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