Solution structures of thiopeptide antibiotics

Richard J. Lewis; Rachael A. Hughes; Lilian Alcaraz; Stewart P. Thompson; Christopher J. Moody

doi:10.1039/B609282A

Solution structures of thiopeptide antibiotics

Richard J. Lewis,^a Rachael A. Hughes,^b Lilian Alcaraz,^a Stewart P. Thompson^b and Christopher J. Moody*^b^c

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* Corresponding authors

^a AstraZeneca R&D Charnwood, Bakewell Road, Loughborough, UK

^b Department of Chemistry, University of Exeter, Stocker Road, Exeter, UK

^c School of Chemistry, University of Nottingham, University Park, Nottingham, UK
E-mail: c.j.moody@nottingham.ac.uk

Abstract

A detailed NMR study of the thiopeptide amythiamicin D establishes its solution conformation and the presence of a single intramolecular hydrogen bond involving NH13 and O28, and also provides the first evidence for self-association of thiopeptides in solution.

Supplementary files

Publication details

The article was received on 30 Jun 2006, accepted on 03 Aug 2006 and first published on 24 Aug 2006

Article type: Communication

DOI: 10.1039/B609282A

Citation: Chem. Commun., 2006,0, 4215-4217

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Solution structures of thiopeptide antibiotics

R. J. Lewis, R. A. Hughes, L. Alcaraz, S. P. Thompson and C. J. Moody, Chem. Commun., 2006, 0, 4215
DOI: 10.1039/B609282A
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Chemical Communications

Solution structures of thiopeptide antibiotics

Abstract

Supplementary files

Publication details

Solution structures of thiopeptide antibiotics

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