Issue 25, 2006
From the journal:

Chemical Communications

Extended ethidium bromide analogue as a triple helix intercalator: synthesis, photophysical properties and nucleic acids binding†

Victor K. Tam,a   Qi Liua  and  Yitzhak Tor*a  

* Corresponding authors

a Department of Chemistry and Biochemistry, University of California, San Diego
E-mail: ytor@ucsd.edu

Abstract

Ethidium bromide has been extended by fusing an additional aromatic ring resulting in a larger intercalator with increased affinity for poly r(A)·r(U), poly d(A)·d(T) and triple helices when compared to the parent heterocycle.

Graphical abstract: Extended ethidium bromide analogue as a triple helix intercalator: synthesis, photophysical properties and nucleic acids binding

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Article information

DOI
https://doi.org/10.1039/B604281C
Article type
Communication
Submitted
23 Mar 2006
Accepted
10 May 2006
First published
26 May 2006

Chem. Commun., 2006, 2684-2686

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Extended ethidium bromide analogue as a triple helix intercalator: synthesis, photophysical properties and nucleic acids binding

V. K. Tam, Q. Liu and Y. Tor, Chem. Commun., 2006, 2684 DOI: 10.1039/B604281C

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